Computer Science > Computation and Language
arXiv:2609.24799 (cs)
[Submitted on 21 Sep 2026]
Title:When Quantization Preserves Accuracy but Not Evidence: Explanation-Aware Post-Training Quantization for Medical LLMs
Authors:Yeji Kim, Mi-Young Kim, Randy Goebel
View a PDF of the paper titled When Quantization Preserves Accuracy but Not Evidence: Explanation-Aware Post-Training Quantization for Medical LLMs, by Yeji Kim and 2 other authors
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Abstract:Post-training quantization (PTQ) enables efficient deployment of large language models, and PTQ methods are usually optimized and evaluated with generic reconstruction, perplexity, or answer accuracy. But in explanation-critical domains, preserving only the final answer may be insufficient, since users may also inspect generated rationales to judge whether a prediction is trustworthy. We study this issue in medical multiple-choice question answering, where rationales should provide evidence that supports the selected answer.
We propose an explanation-aware objective for transformation-based PTQ. Our method builds an offline faithfulness cache from full-precision teacher rationales and uses it during optimization to preserve answer-supporting evidence tokens and evidence-conditioned answer behavior. We instantiate it on OSTQuant under W4A4KV4 quantization and evaluate four 7B--8B medical and instruction-tuned LLMs on MedExQA, MedExpQA, and ChallengeClinicalQA. While a same-calibration OSTQuant baseline preserves task accuracy, it can substantially weaken answer-supporting rationales. Our objective is to preserve the full-precision model's answer-supporting behavior rather than improve gold-label accuracy, and our method better preserves the full-precision model's answer behavior and rationale-to-answer support. These results suggest that PTQ for explanation-critical settings should evaluate preservation of answer-supporting evidence, not only answer accuracy. Code and evaluation scripts are available at this https URL.
Subjects:
Computation and Language (cs.CL); Artificial Intelligence (cs.AI)
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arXiv:2609.24799 [cs.CL]
(or
arXiv:2609.24799v1 [cs.CL] for this version)
https://doi.org/10.48550/arXiv.2609.24799
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arXiv-issued DOI via DataCite (pending registration)
Submission history
From: Yeji Kim [view email]
[v1]
Mon, 21 Sep 2026 15:59:06 UTC (128 KB)
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